Surgical Oncology News

This section features a sampling of news related to surgical oncology from the popular press, from press releases received, or SSO news directly pertinent to SSO members.

Family history linked to contralateral breast cancer risk

Author: HemOnc Today
Jan 31, 2013

Women aged younger than 45 years with a family history of breast cancer carried a 2.5-fold risk for contralateral disease, according to results of a population-based case-control study.

Researchers conducted the investigation to compare women with contralateral breast cancer with those with unilateral breast cancer. Eligible participants had a family history and a negative test for BRCA1 and BRCA2 mutations.

There were 594 women in the contralateral group and 1,119 controls with unilateral disease. Researchers observed an association between family history of breast cancer and increased risk for contralateral disease. The highest risk was reported among women aged younger than 45 years who also had a first-degree relative who developed breast cancer at this age (RR=2.5; 95% CI, 1.1-5.3). Researchers also observed a high risk in women who had first-degree relatives with bilateral disease (RR=3.6; 95% CI, 2.0-6.4).

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