Fellows National Video Conference Series Articles August 2016

Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial.

Claus Rödel*, Ullrich Graeven*, Rainer Fietkau, Werner Hohenberger, Torsten Hothorn, Dirk Arnold, Ralf-Dieter Hofh einz, Michael Ghadimi, Hendrik A Wolff , Marga Lang-Welzenbach, Hans-Rudolf Raab, Christian Wittekind, Philipp Ströbel, Ludger Staib, Martin Wilhelm, Gerhard G Grabenbauer, Hans Hoff manns, Fritz Lindemann, Anke Schlenska-Lange, Gunnar Folprecht, Rolf Sauer*, Torsten Liersch*, on behalf of the German Rectal Cancer Study Group

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Extended Intervals after Neoadjuvant Therapy in Locally Advanced Rectal Cancer: The Key to Improved Tumor Response and Potential Organ Preservation

Christian P Probst, MD, Adan Z Becerra, BA, Christopher T Aquina, MD, Mohamedtaki A Tejani, MD, Steven D Wexner, MD, FACS, Julio Garcia-Aguilar, MD, PhD, Feza H Remzi, MD, FACS, David W Dietz, MD, FACS, John RT Monson, MD, FACS, Fergal J Fleming, MD, on behalf of the Consortium for Optimizing the Surgical Treatment of Rectal Cancer (OSTRiCh)

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Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study

K. Bujko*, L. Wyrwicz, A. Rutkowski, M. Malinowska, L. Pietrzak, J. Kryn´ ski, W. Michalski, J. Olędzki, J. Kusnierz, L. Zając, M. Bednarczyk, M. Szczepkowski, W. Tarnowski, E. Kosakowska, J. Zwolinski, M. Winiarek, K. Wisniowska, M. Partycki, K. Bęczkowska, W. Polkowski, R. Stylin´ ski1, R. Wierzbicki, P. Bury, M. Jankiewicz, K. Paprota, M. Lewicka, B. Ciseł, M. Skórzewska, J. Mielko, M. Bębenek, A. Maciejczyk, B. Kapturkiewicz, A. Dybko, Ł. Hajac, A. Wojnar, T. Lesniak, J. Zygulska, D. Jantner, E. Chudyba, W. Zegarski, M. Las-Jankowska, M. Jankowski, L. Kołodziejski, A. Radkowski, U. Zelazowska-Omiotek, B. Czeremszynska, L. Kępka, J. Kolb-Sielecki, Z. Toczko, Z. Fedorowicz, A. Dziki, A. Danek, G. Nawrocki, R. Sopyło, W. Markiewicz, P. Kędzierawski & J. Wydmanski for the Polish Colorectal Study Group

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Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers

Aung Ko Win, MBBS, MPH, Susan Parry, MB ChB, FRACP, Bryan Parry, MD, FRACS, Matthew F. Kalady, MD, Finlay A. Macrae, MBBS, MD, FRACP, FRCP, AGAF, Dennis J. Ahnen, MD, AGAF, Graeme P. Young, MBBS, MD, FRACP, FTSE, AGAF, Lara Lipton, PhD, FRACP, Ingrid Winship, MB ChB, MD, FRACP, Alex Boussioutas, MBBS, PhD, FRACP, Joanne P. Young, PhD, Daniel D. Buchanan, PhD, Julie Arnold, RN2, Loı¨c Le Marchand, MD, PhD, Polly A. Newcomb, PhD, Robert W. Haile, DrPH, Noralane M. Lindor, MD, Steven Gallinger, MD, MSc, FRCSC, John L. Hopper, PhD, and Mark A. Jenkins, PhD

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

D.T. Le, J.N. Uram, H. Wang, B.R. Bartlett, H. Kemberling, A.D. Eyring, A.D. Skora, B.S. Luber, N.S. Azad, D. Laheru, B. Biedrzycki, R.C. Donehower, A. Zaheer, G.A. Fisher, T.S. Crocenzi, J.J. Lee, S.M. Duffy, R.M. Goldberg, A. de la Chapelle, M. Koshiji, F. Bhaijee, T. Huebner, R.H. Hruban, L.D. Wood, N. Cuka, D.M. Pardoll, N. Papadopoulos, K.W. Kinzler, S. Zhou, T.C. Cornish, J.M. Taube, R.A. Anders, J.R. Eshleman, B. Vogelstein, and L.A. Diaz, Jr.

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Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome

Matthew B. Yurgelun, Brian Allen, Rajesh R. Kaldate, Karla R. Bowles, Thaddeus Judkins, Praveen Kaushik, Benjamin B. Roa, Richard J. Wenstrup, Anne-Renee Hartman, and Sapna Syngal

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Phase II Trial of Hepatic Artery Infusional and Systemic Chemotherapy for Patients With Unresectable Hepatic Metastases From Colorectal Cancer

Michael I. D'Angelica, MD, Camilo Correa-Gallego, MD, Philip B. Paty, MD, Andrea Cercek, MD, Alexandra N. Gewirtz, BA, Joanne F. Chou, MPH, Marinella Capanu, PhD, T. Peter Kingham, MD, Yuman Fong, MD, Ronald P. DeMatteo, MD, Peter J. Allen, MD, William R. Jarnagin, MD, and Nancy Kemeny, MD

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Prognostic Relevance of Palliative Primary Tumor Removal in 37,793 Metastatic Colorectal Cancer Patients: A Population-based, Propensity Score–adjusted Trend Analysis

Ignazio Tarantino, MD, MSc, Rene Warschkow, MD, MSc, Mathias Worni, MD, MHS, Thomas Cerny, MD, Alexis Ulrich, MD, Bruno M. Schmied, MD, MBA, and Ulrich Guller, MD, MHS

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Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials

Matthieu Faron, Jean-Pierre Pignon, David Malka, Abderrahmane Bourredjem, Jean-Yves Douillard, Antoine Adenis, Dominique Elias, Olivier Bouche´, Michel Ducreux

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