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HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY

Weekly Update

Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients

Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis

Citation: McDonald, KA., Kawaguchi, T., Qi, Q. et al. Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients. Ann Surg Oncol 26, 2191–2199 (2019). https://doi.org/10.1245/s10434-019-07338-3

Synopsis: Intra-tumor heterogeneity is a known mechanism of breast cancer progression and metastasis. The authors found that it correlates with less immune cell infiltration, less cytolytic activity, and worse survival in breast cancer utilizing computational analyses including Mutant Allele Tumor Heterogeneity (MATH) algorithm.

Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis

Citation: Ratti, F., Fiorentini, G., Cipriani, F. et al. Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis. Ann Surg Oncol 26, 564–575 (2019). https://doi.org/10.1245/s10434-018-6811-0

Synopsis: The aim of this study was to compare patients undergoing MILS and open liver resections with associated lymphadenectomy for biliary tumors (intrahepatic cholangiocarcinoma and gallbladder cancer) in a case-matched analysis using propensity scores. Laparoscopy proved to be a valid option since it allows to maintain the advantages of minimally invasive approach, without compromising the accuracy and the outcomes of nodal dissection, specifically evaluated in terms of lymphadenectomy-related morbidity.

Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis

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ASO – The Leading Resource in Surgical Oncology

Annals of Surgical OncologyAnnals of Surgical Oncology (ASO) hails 2019 as a year of growth and influence with a 13% increase in editorials, the addition of a two new editorial sections and the introduction of “ASO Author Reflections.” ASO also had more than 1 million article downloads, a demonstration of the quality and relevance of the research published. Read more about ASO.

ASO is the journal of choice of surgical oncologists and cancer multidisciplinary teams worldwide regarding surgical oncology research and education, and benefits surgeons, oncologists, hematologists, radiologists, general practitioners, pathologists, researchers, academicians, and other clinical professionals interested in all aspects of the surgical treatment of cancer. ASO strives to improve the practice environment in which high-quality surgical oncology care is delivered, to enhance the quality of life and survival of the surgical patient with cancer.

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