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Annals of Surgical Oncology

HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY

Weekly Update

How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery?

How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast Conserving Surgery

Petruolo, O., Sevilimedu, V., Montagna, G. et al.

https://doi.org/10.1245/s10434-020-08593-5

Citation:

Petruolo, O., Sevilimedu, V., Montagna, G. et al. How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery? Ann Surg Oncol 28, 287–294 (2021).

Synopsis: The authors evaluate breast-conserving surgery (BCS) conversion rates with neoadjuvant chemotherapy (NAC) in patients with tumors too large for conservation. Borderline-BCS candidacy, HER2+/triple negative receptor status, tumor size, cN+ status, and mammographic calcifications are factors to consider when selecting patients for downstaging with NAC.

Intraperitoneal CMP-001: A Novel Immunotherapy for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer

Miller, A.M., Lemke-Miltner, C.D., Blackwell, S. et al.

https://doi.org/10.1245/s10434-020-08591-7

Citation: Miller, A.M., Lemke-Miltner, C.D., Blackwell, S. et al. Intraperitoneal CMP-001: A Novel Immunotherapy for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer. Ann Surg Oncol 28, 1187–1197 (2021).

Synopsis:  Peritoneal carcinomatosis of gastrointestinal and pancreaticobiliary cancer is a deadly condition with limited treatment options. CMP-001 is a virus-like particle containing a TLR9 agonist that is shown here to be a new potential effective treatment when given intraperitoneally.

Intraperitoneal CMP A Novel Immunotherapy for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer

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