HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients
Citation: McDonald, KA., Kawaguchi, T., Qi, Q. et al. Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients. Ann Surg Oncol 26, 2191–2199 (2019). https://doi.org/10.1245/s10434-019-07338-3
Synopsis: Intra-tumor heterogeneity is a known mechanism of breast cancer progression and metastasis. The authors found that it correlates with less immune cell infiltration, less cytolytic activity, and worse survival in breast cancer utilizing computational analyses including Mutant Allele Tumor Heterogeneity (MATH) algorithm.
Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis
Citation: Ratti, F., Fiorentini, G., Cipriani, F. et al. Perioperative and Long-Term Outcomes of Laparoscopic Versus Open Lymphadenectomy for Biliary Tumors: A Propensity-Score-Based, Case-Matched Analysis. Ann Surg Oncol 26, 564–575 (2019). https://doi.org/10.1245/s10434-018-6811-0
Synopsis: The aim of this study was to compare patients undergoing MILS and open liver resections with associated lymphadenectomy for biliary tumors (intrahepatic cholangiocarcinoma and gallbladder cancer) in a case-matched analysis using propensity scores. Laparoscopy proved to be a valid option since it allows to maintain the advantages of minimally invasive approach, without compromising the accuracy and the outcomes of nodal dissection, specifically evaluated in terms of lymphadenectomy-related morbidity.
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