HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY
Weekly Update
Neal Bhutiani, Yan Li, Qianqian Zheng, Harshul Pandit, Xiaoju Shi, Yujia Chen, Youxi Yu, Zachary R. Pulliam, Min Tan, and Robert C. G. Martin II
https://doi.org/10.1245/s10434-020-08782-2
Citation: Bhutiani, N., Li, Y., Zheng, Q. et al. Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma. Ann Surg Oncol 27, 4348–4359 (2020).
Synopsis: Electrochemotherapy (ECT) with IRE and FOLFIRINOX resulted in increased tumor-cell apoptosis in mice models. In five patients, ECT with either FOLFIRINOX or gemcitabine was well tolerated and resulted in no dose-limiting toxicities.
Giacomo Montagna, Anita Mamtani, Andrea Knezevic, Edi Brogi, Andrea V. Barrio, and Monica Morrow
https://doi.org/10.1245/s10434-020-08650-z
Citation: Montagna, G., Mamtani, A., Knezevic, A. et al. Selecting Node-Positive Patients for Axillary Downstaging with Neoadjuvant Chemotherapy. Ann Surg Oncol 27, 4515–4522 (2020).
Synopsis: Here we evaluate how often node-positive patients avoid ALND with NAC and identify predictors of retrieval of ≥3 SLNs and ALND avoidance. ALND was spared in 41% of patients; this was associated with receptor status, grade, and LVI.
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