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HIGHLIGHTED ARTICLES FROM ANNALS OF SURGICAL ONCOLOGY

Weekly Update

How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery?

Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial

Petruolo, O., Sevilimedu, V., Montagna, G. et al.

Ann Surg Oncol 28, 287–294 (2021).

https://rdcu.be/ckzXq

Petruolo, O., Sevilimedu, V., Montagna, G. et al.  How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery? Ann Surg Oncol 28, 287–294 (2021).

Synopsis:  In this article the authors evaluate breast-conserving surgery (BCS) conversion rates with neoadjuvant chemotherapy (NAC) in patients with tumors too large for conservation. Borderline-BCS candidacy, HER2+/triple negative receptor status, tumor size, cN+ status, and mammographic calcifications are factors to consider when selecting patients for downstaging with NAC.

Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial

Lurvink, R.J., Tajzai, R., Rovers, K.P. et al.

Ann Surg Oncol 28, 265–272 (2021). https://rdcu.be/ckzYV

Citation: Lurvink, R.J., Tajzai, R., Rovers, K.P. et al.  Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial.  Ann Surg Oncol 28, 265–272 (2021).

Synopsis: Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy as a palliative treatment for unresectable isolated colorectal peritoneal metastases results in concentrations equal to those reached with systemic chemotherapy.

Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial

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